Furanylfentanyl HCL

Furanylfentanyl HCL

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Description

Furanylfentanyl HCL (Fu-F) is an opioid analgesic that is an analog of fentanyl and has been sold as a designer drug. It has an ED50 value of 0.02 mg/kg in mice. This makes it approximately one fifth as potent as fentanyl.

Furanyl Fentanyl is a new designer opioid drug. It is a derivative of fentanyl with two distinctive
characteristics:
1) higher liposolubility that allows its rapid absorption into general circulation
2) It binds to µ-opioid receptors with significant higher affinity than morphine.
These characteristics give furanyl fentanyl a highly risky pharmacological profile.
In the last several years there has been an increase in deaths due to the use of this designer opioid.
Furthermore, it has been reported that it might be present in cocaine crack and other illicit drugs
sold on the black market.

FURANYLFENTANYL HCL SIDE EFFECTS
Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.

Life-threatening adverse reactions caused by Furanylfentanyl HCL use have been observed in Sweden and Canada. At least seven deaths in Cook County, Illinois, have been linked to Furanylfentanyl HCL in 2016, with additional deaths in suburban Chicago in 2017.

What is furanylfentanyl HCL? Well, it’s never been sold as a prescription pharmaceutical. Unless you’ve been buying opioids through non-medical channels, you are unlikely to have encountered it. Furanylfentanyl HCL is a chemical relative of the medically useful drug, fentanyl, and is the latest of fentanyl analogues that clandestine chemists have been making to circumvent international controlled substances laws.

Fentanyl, first made by the legendary chemist Paul A. Janssen in 1960, was originally intended as an intravenous anesthetic together with other drugs. If you’ve had a wisdom tooth extraction or colonoscopy, chances are that you have been the beneficiary of fentanyl.

Unfortunately, fentanyl analogues have been re-emerging in the recreational drug trade since an insurgence in the mid-198

0s. While fentanyl has a peak effect similar to other opioids, it can be achieved with doses 50 to 100 times less than morphine. Therefore, fentanyl and its chemical relatives have been more easily transported, and trafficking in those without controlled substances-designation has been largely legal.

An unrelated synthetic opioid first made at Upjohn in the 1970s called U-47,700 was placed on Schedule I earlier this month. U-47,700 was foundtogether with fentanyl in the blood of the musician, Prince Rogers Nelson, when he was found dead at his Minnesota home and studio. Buried within a 1978 patent, U-47,700 exemplifies the extent to which recreational drug users will scour the peer-reviewed and patent literature for research chemicals with opioid effects but which were not, at the time, illegal.

The fentanyl class of opioids are generally more potent than any other group of naturally occurring or synthetic opioids. What this means to non-pharmaceutical users is that very small differences in measurements can lead to catastrophic health effects. Street drugs don’t come with a certificate of analysis as to their content, so small doping of heroin or cocaine with fentanyl or a chemical relative can be potentially lethal to the user.

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